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However the introduction of different immunohistochemically compatible markers now enables multiple subpopulations of newborn neurons to be analyzed in the same animal as in a line-up, revealing the relationships between these subpopulations in response to specific influences or conditions.
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We have previously shown that Notch signaling plays an important role in cell fate within the ARC of mice.
Using a Brd U birthdating paradigm, we determined the percentage of NPY and Kisspeptin neurons born on embryonic days 11.5, 12.5, and 13.5.
Neurons in the cerebral cortex stratify on the basis of their time of origin, axonal terminations and the molecular identities assigned during early development.… continue reading »
In vivo birthdating of trigeminal sensory neurons. To distinguish early-born from late-born neurons in live embryos, we devised a method called BAPTI birthdating.… continue reading »
Analyzing the variation in different subpopulations of newborn neurons is central to the study of adult hippocampal neurogenesis. The acclaimed working hypothesis.… continue reading »
Rbpj-κ mediated Notch signaling plays a critical role in development of hypothalamic Kisspeptin neurons. Using a BrdU birthdating paradigm.… continue reading »
Desroziers et al. performed similar BrdU birthdating of ARC Kisspeptin neurons within the rat and report that neurogenesis occurs over a more broad window.… continue reading »
MSc Neuroscience, King's College London, Institute of Psychiatry, Neuroscience, Neurodegeneration. Birthdating dopaminergic neurons in the mouse olfactory bulb.… continue reading »